I would abandon cooking the bird stuffed. It only serves to prolong the cooking time and add grease to the stuffing (unnecessary for such a rich meal!). Cook your stuffing on the side.
I use this formula for cooking turkey by time/weight. From The Joy Of Cooking:
Directly upon removal from the refrigerator, place the bird in a preheated 450 oven. Reduce the heat immediately to 350 or to 325 for large turkeys.
Allow 20 to 25 minutes per pound for birds up to six pounds. For larger birds, allow 15 to 20 minutes per pound. For turkeys weighing over 16 pounds, allow 13 to 15 minutes per pound.
I know this sounds strange but it really works.
By temperature with a probe thermometer, I use the following formula from Good Eats. I brined the turkey which I highly recommend. Be sure not to try to brine a pre-stuffed turkey. Brining adds flavor and enables the turkey to retain moisture - especially with those big mutant birds (the kind that always finds its way to my table).
Good Eats Roast Turkey ... Recipe courtesy Alton Brown
1 (14 to 16 pound) frozen young turkey
For the brine:
1 cup kosher salt
1/2 cup light brown sugar
1 gallon vegetable stock
1 tablespoon black peppercorns
1/2 tablespoon allspice berries
1/2 tablespoon candied ginger
1 gallon iced water
For the aromatics:
1 red apple, sliced
1/2 onion, sliced
1 cinnamon stick
1 cup water
4 sprigs rosemary
6 leaves sage
Canola oil
Combine all brine ingredients, except ice water, in a stockpot, and bring to a boil. Stir to dissolve solids, then remove from heat, cool to room temperature, and refrigerate until thoroughly chilled.
Early on the day of cooking, (or late the night before) combine the brine and ice water in a clean 5-gallon bucket. Place thawed turkey breast side down in brine, cover, and refrigerate or set in cool area (like a basement) for 6 hours. Turn turkey over once, half way through brining.
A few minutes before roasting, heat oven to 500 degrees. Combine the apple, onion, cinnamon stick, and cup of water in a microwave safe dish and microwave on high for 5 minutes.
Remove bird from brine and rinse inside and out with cold water. Discard brine.
Place bird on roasting rack inside wide, low pan and pat dry with paper towels. Add steeped aromatics to cavity along with rosemary and sage. Tuck back wings and coat whole bird liberally with canola (or other neutral) oil.
Roast on lowest level of the oven at 500 degrees F. for 30 minutes. Remove from oven and cover breast with double layer of aluminum foil, insert probe thermometer into thickest part of the breast and return to oven, reducing temperature to 350 degrees F. Set thermometer alarm (if available) to 161 degrees. A 14 to 16 pound bird should require a total of 2 to 2 1/2 hours of roasting. Let turkey rest, loosely covered for 15 minutes before carving.
Yield: 10 to 12 servings