I like it up as it helps get the harder to clean items clean. However, you then have to grab the business end to put them away which is somewhat less sanitary than the handle end being up.
The ideal situation is two dishwashers. You alternate loading one and setting from the clean one. rarely have to put things away...
D: Whichever way you pick it up. Because if it's on the roller it becoms a cat toy
Or still in the cabinet in the hall just outside the bathroom door.